{"id":49680,"date":"2024-07-18T10:43:55","date_gmt":"2024-07-18T03:43:55","guid":{"rendered":"https:\/\/wiralabanalitika.com\/?post_type=product&p=49680"},"modified":"2024-07-18T10:43:56","modified_gmt":"2024-07-18T03:43:56","slug":"stellar-mass-spectrometry","status":"publish","type":"product","link":"https:\/\/wiralabanalitika.com\/en\/product\/stellar-mass-spectrometry\/","title":{"rendered":"Stellar Mass Spectrometry"},"content":{"rendered":"

Accelerate Biomarker Translation with the Thermo Scientific\u2122 Stellar\u2122 Mass Spectrometer!<\/span><\/h1>\n

10x higher sensitivity than other instruments when targeting 5X more analytes using faster gradients.
\nTake biomarker candidates from discovery to validation with greater efficiency, confidence and lower cost. Thermo Scientific\u2122 Stellar\u2122 mass spectrometers are designed to verify more biomarkers in less time with the latest technology combined with robust quantitation.
\n– Achieve biased systems biology analysis by quantifying nearly 10,000 peptides in one hour.
\n– Increase the power of quantitative studies using absolute quantitation on a larger panel of targets with 4X the sample throughput.
\n– Utilize improved sensitivity to expand targeted pathway analysis while reducing missing values for input samples.
\n– Overcome challenging matrix backgrounds using fast and sensitive MS3 Synchronous Precursor Selection (SPS) acquisition with full scan.
\n– Accelerate targeted method generation and implementation using a variety of targeted and non-targeted data acquisition schemes.<\/p>\n

Expanded Scale<\/strong>
\nTransitioning putative biomarkers from discovery to validation requires an efficient workflow to verify the diagnostic value of each candidate, both individually and in signaling pathways. To improve biomarker stratification, highly multiplexed targeted quantitation is used, improving sensitivity and specificity across a greater number of samples in a study. Stellar mass spectrometers expand the experimental scale, allowing quantitative characterization of multiple signaling pathways in a single experiment while maintaining the high throughput required for comprehensive systems biology evaluation.<\/p>\n

Higher Sensitivity<\/strong>
\nIncreased sensitivity is critical for targeted quantitative analysis of low-input samples, such as single cells and low abundance analytes in bulk samples. By increasing sensitivity, post-acquisition automated peak integration becomes more effective, resulting in higher quantitation quality and confidence, especially when measuring small changes between biological groups or cells. Stellar mass spectrometers excel in this area, offering high ion transmission efficiency, effective ion detection from low-pressure linear ion traps, and increased sensitivity through extended scale detectors. These capabilities facilitate targeted signaling pathway analysis on single cells in a wide range of expression levels. Lower detection limits reduce the risk of data loss, ensuring highly reliable quantitative results.<\/p>\n

Enhanced Specificity<\/strong>
\nEffective biomarker quantitation relies on sensitivity and specificity to ensure the measured signal is truly from the targeted analyte. Complex biological matrices pose significant quantitative challenges due to co-eluting isobaric and isomeric interferences, which may not be fully overcome by MS2 acquisition. To reduce background interferences and increase specificity in distinguishing isomeric compounds in complex matrices, MS3 acquisition becomes a more efficient and effective solution. Stellar mass spectrometers excel with fast tMS3 acquisition speeds of up to 40 Hz, supported by automated method generation via Conductor’s PRM software tool. The increased specificity of tMS3 acquisition improves the limit of detection (LOD) and limit of quantitation (LOQ), allowing simultaneous quantitation of multiple analytes in a single spectrum-all done with fast ultra-high-performance liquid chromatography (UHPLC) gradients.<\/p>\n

Unmatched Productivity<\/strong>
\nMethod optimization for small molecule analysis is often the most time-consuming stage in performing selected reaction monitoring (SRM) quantification. SRM acquisition parameters must be determined for each analyte, including ionization polarity, precursor and product ion m\/z values, and appropriate collision energies and residence times. Typically, standards are analyzed using flow injection analysis (FIA) or direct infusion to establish SRM parameters, followed by matrix-matched analysis to evaluate potential background interferences.
\nStellar mass spectrometers combine analytical flexibility with fast polarity playback for full scan MS acquisition and MS2 acquisition of chromatographic separations. Complete method optimization can be achieved in hours rather than days or weeks, allowing researchers to immediately begin analysis of critical samples and complete experimental studies with increased confidence and efficiency.<\/p>\n

\"spektrometer<\/p>\n

For more information, contact our team at sales@wiralab.co.id<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Accelerate Biomarker Translation with the Thermo Scientific\u2122 Stellar\u2122 Mass Spectrometer! 10x higher sensitivity than other instruments when targeting 5X more analytes using faster gradients. Take biomarker candidates from discovery to validation with greater efficiency, confidence and lower cost. Thermo Scientific\u2122 Stellar\u2122 mass spectrometers are designed to verify more biomarkers in less time with the latest […]<\/p>\n","protected":false},"featured_media":49568,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false},"product_brand":[],"product_cat":[125,84,76,15],"product_tag":[],"class_list":{"0":"post-49680","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-chemicals","7":"product_cat-lc-ms-system","8":"product_cat-product","9":"product_cat-uncategorized","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"acf":[],"yoast_head":"\nStellar Mass Spectrometry - Wiralab<\/title>\n<meta name=\"description\" content=\"Stellar mass spectrometers are designed with the latest breakthrough technology, having 10x better sensitivity than other instruments.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wiralabanalitika.com\/en\/product\/stellar-mass-spectrometry\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stellar Mass Spectrometry\" \/>\n<meta property=\"og:description\" content=\"Stellar mass spectrometers are designed with the latest breakthrough technology, having 10x better sensitivity than other instruments.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wiralabanalitika.com\/en\/product\/stellar-mass-spectrometry\/\" \/>\n<meta property=\"og:site_name\" content=\"Wiralab\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-18T03:43:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wiralabanalitika.com\/wp-content\/uploads\/2024\/06\/3-2.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/wiralabanalitika.com\\\/en\\\/product\\\/stellar-mass-spectrometry\\\/\",\"url\":\"https:\\\/\\\/wiralabanalitika.com\\\/en\\\/product\\\/stellar-mass-spectrometry\\\/\",\"name\":\"Stellar Mass Spectrometry - 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